Serotonin    1 2 3 4 5 6 7

Index

A possible role for saliva as a diagnostic fluid in patients with chronic pain. [Review] [152 refs]

Activation of 5-HT2A receptors potentiates pain produced by inflammatory mediators.

Effect of intrathecal serotonin on nociception in rats: influence of the pain test used.

Modulation of neuropathic pain in rats by intrathecally injected serotonergic agonists.

Morphine and norepinephrine-induced antinociception at the spinal level is mediated by adenosine.

Pain and synovial fluid concentration of serotonin in arthritic temporomandibular joints.

Pain treatment of fibromyalgia by acupuncture [letter].

Pain, tenderness, wheal and flare induced by substance-P, bradykinin and 5-hydroxytryptamine in humans.

[Role of the spinal serotoninergic, noradrenergic and dopaminergic systems in the mechanism of analgesia]. [French]

The effect of serotonin antibodies on the development of a neuropathic pain syndrome]. [Russian]

The nociceptive flexion reflex as a tool for exploring pain control systems in headache and other pain syndromes. [Review] [61 refs]

Yang SW. Zhang ZH. Chen JY. Xie YF. Qiao JT. Dafny N.

Department of Neurobiology, Shanxi Medical College, Taiyuan, P.R. China.

Morphine and norepinephrine-induced antinociception at the spinal level is mediated by adenosine.

Neuroreport. 5(12):1441-4, 1994 Jul 21.

Abstract:

The purpose of this study was to examine whether adenosine or serotonin is involved in mediation of the antinociception produced by norepinephrine at the spinal cord level. Aminophylline, an adenosine receptor antagonist and naloxone given intrathecally (i.t.) were used to test the antinociception produced by i.t. norepinephrine, serotonin, morphine or the adenosine receptor agonist 5'-N-ethylcarboxamidoadenosine (NECA) by using the tail-flick assay in rats. It was observed that (1) aminophylline blocked the antinociception produced by norepinephrine, but exhibited no effect on the antinociception produced by serotonin, (2) aminophylline blocked the antinociception produced by morphine similarly to naloxone, (3) aminophylline blocked the antinociception produced by NECA and (4) naloxone failed to block the antinociception produced by NECA and serotonin. The results suggest that adenosine is involved in mediation of the norepinephrine-produced antinociception at the spinal level and that norepinephrine and adenosine may act in a sequential manner in norepinephrine-induced antinociception.